ANTACIDS (Like Rolaids)
Antacids, like Rolaids, neutralize the acid in your stomach. Antacids work quickly, but effects last for only 1-3 hours after use.3
Nexium 24HR
Frequent heartburn can be treated with a proton pump inhibitor (PPI) like Nexium 24HR. Nexium 24HR stops the production of acid before it starts. By turning off many of the pumps that produce acid, one pill a day is all you need to control frequent heartburn.4 This treatment may take 1-4 days for full effect. Learn more.
H2s (Like Pepcid AC)
Histamine blockers (H2s), like Pepcid AC, block just one of the signals that tell your body to produce acid. They begin working within 30 minutes, for up to 12 hours.5-9 H2s can become less effective if used repeatedly.7-9
PPIS VS. ANTACIDS (Like Rolaids)
What is the difference between PPIs and Antacids? Antacids neutralize stomach acid and work quickly, but effects last for only 1-3 hours after use.3 PPIs, like Nexium 24HR, work differently by blocking the source of acid production.4 PPIs may take 1-4 days for full effect.10
PPIS VS. H2 BLOCKERS (Like Pepcid AC)
What’s the difference between PPIs and H2s? Histamine blockers (“H2RAs” or Histamine-2 Receptor Antagonists) only block one of the signals that tell your body to make acid. They start working within 30 minutes, last for up to 12 hours, but become less effective if used repeatedly.5-9
PPIs, like Nexium 24HR, work differently by blocking the source of acid production with just 1 pill every 24 hours.11 PPIs may take 1-4 days for full effect.
REFERENCES :
∆ 2018 IQVIA Provoice Survey for OTC PPIs
† 2017 IMS Global OTC Analysis
3. Robinson, M., Rodriguez‐Stanley, S., Miner, P. B., McGuire, A. J., Fung, K., & Ciociola, A. A. (2002). Effects of antacid formulation on postprandial oesophageal acidity in patients with a history of episodic heartburn. Alimentary Pharmacology & Therapeutics, 16(3), 435-44
4. How Nexium Works. (2018). Retrieved from https://www.purplepill.com/heartburn-relief/how-nexium-works.html
5. H2 Blockers. (2016). International Foundation for Gastrointestinal Disorders. Retrieved from https://www.aboutgerd.org/medications/h2-blockers.html
6. H2-blockers: Onset time. (n.d.). OpenAnesthesia. Retrieved from https://www.openanesthesia.org/h2-blockers_onset_time/
7. McRorie, J. W., Kirby, J. A., & Miner, P. B. (2014). Histamine2-receptor antagonists: rapid development of tachyphylaxis with repeat dosing. World Journal of Gastrointestinal Pharmacology and Therapeutics, 5(2), 57
8. Miner Jr., P. B., Allgood, L. D., & Grender, J. M. (2007). Comparison of gastric pH with omeprazole magnesium 20.6 mg (Prilosec OTC) om famotidine 10 mg (Pepcid AC) bd and famotidine 20 mg bd over 14 days of treatment. Alimentary Pharmacology & Therapeutics, 25(1), 103-109
9. Hurlimann, S., Abbühl, B., Inauen, W., & Halter, F. (1994). Comparison of acid inhibition by either oral high‐dose ranitidine or omeprazole. Alimentary Pharmacology & Therapeutics, 8(2), 193-201
10. Shin, J.M., Sachs G. (2008). Pharmacology of proton pump inhibitors. Current Gastroenterology Reports, Dec; 10(6), 528–534. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855237
11. Dosage and administration for Nexium. (2018). Retrieved from https://www.nexiumtouchpoints.com/nexium-information/dosage-administration.html
